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roastokra73 (#754) 154 days ago
Ngements with the N-terminal Asp he ly (DFG) motif of the activation loop, with some, like FGFR1 kinase, appearing refractory to this so-called `DFG flip'. Current inhibitor-bound structures have unexpectedly revealed FGFR1 for the first time in a `DFG-out' state. Right here we use conformationally selective inhibitors as chemical probes for interrogation of your structural and dynamic characteris